Metabolism Ketamine is metabolized via N-dealkylation to the Energetic metabolite norketamine mainly by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation from the cyclohexone ring to type hydroxynorketamine compounds through CYP-dependent pathways, which are conjugated with glucuronic acid and s